Two teenage boys have died after a horror crash in Perth’s north-east.

Western Australia Police said the incident occurred at about 10.20pm on Saturday when a BMW 3 Series sedan was travelling north at Bullsbrook on Railway Parade.

The vehicle left the roadway before it struck several trees, they said.

The driver and a passenger, both aged 16, died at the scene from their injuries.

A further two teens, both aged 17, were taken to Royal Perth Hospital for treatment of serious injuries.

Major Crash investigators were conducting a scene examination on Sunday.

WA Police asked those who may have witnessed the crash to contact Crime Stoppers online.

Anyone with CCTV, dashcam or mobile phone footage relating to the crash can upload it directly to investigators through the Force Evidence Submission Portal. 

WA Police said the incident occurred at about 10.20pm on Saturday when a BMW 3 Series sedan was travelling north at Bullsbrook on Railway Parade

Major Crash investigators were conducting a scene examination