“It brings up an interesting point that we can talk about,” she said, “the labeling of things and how attached we become to them for so many reasons. It feels like there’s a road map, at least, that you have for things.”

“We’ve come to learn that this is not a rare occurrence,” Sigler continued of medical misdiagnoses, “especially when it comes to MS.”

A 2019 study led by Cedars-Sinai found that nearly one in five patients with “an established diagnosis” were misdiagnosed.

Sigler, 45, also urged her co-host not to feel as if she’s at fault for her current situation.

“Everything you did and shared and were and are to so many people doesn’t go anywhere,” she added. “This new information that you have in your life, that doesn’t take away anything that you did. You didn’t mislead anyone.”

As Applegate continues her journey to find an answer, keep reading for a look back at what she had shared about her health battle.