Dane was born on November 9, 1972 and raised in California. His father, a Navy man, died of a gunshot wound when he was 7. After high school, he moved to Los Angeles to purse acting, landing guest roles on shows like “Saved by the Bell,” “Married…With Children,” “Charmed” and “X-Men: the Last Stand,” and one season of the short-lived medical drama “Gideon’s Crossing.”

His big break arrived in the mid-2000s, when he was cast as Dr. Mark Sloan, a.k.a. McSteamy, on the ABC medical drama “Grey’s Anatomy,” a role he would play from 2006 until 2012 and reprise in 2021. In 2019, he did a complete 180 and became Cal Jacobs, a troubled married man, in HBO’s provocative drama, “Euphoria,” a role he continued in up until his death.

Dane also starred as Tom Chandler, the captain of a U.S. Navy destroyer at sea after a global catastrophe wiped out most of the world’s population, in the TNT drama “The Last Ship.” In 2017, production was halted as Dane battled depression.

In April 2025, Dane announced he had been diagnosed with ALS, a progressive disease that attacks nerve cells controlling muscles throughout the body.