If we stayed up with you all night, rest assured we’re probably watching Grey’s Anatomy.

The heart-stirring medical drama premiered as a mid-season replacement on March 27, 2005, and viewers picked it, chose it, loved it so much, it’s now the longest-running scripted prime-time show on ABC.

Over the course of 21 years, the unsettling death count among the doctors at Seattle Grace have deterred neither patients nor more bright, hot medical minds from joining the staff. And the doors keep revolving, with Ellen Pompeo, Chandra Wilson and James Pickett Jr. the only remaining stars from season one, though Meredith Grey’s physical presence hasn’t been a constant since 2022.

“I’ve been doing it for 20 years, so it was time to step away,” Pompeo, who’s also an executive producer, told El Pais in April. “I’m very lucky to be able to get to work sometimes and take time off.”

Kim Raver and Kevin McKidd, who play onscreen loves Teddy and Owen, are the latest regulars whose exits have been plotted, with series creator Shonda Rhimes stating, “It is both bittersweet and joyful to give this couple the happy ending their story deserves.”